Changes in the definition of a Clinical Trial related to the Clinical Trial Finance initiate the following variations that have to be reported to the competent Health Authorities:

• T.IV.1 Agreement - co-sponsor - amendment
• T.IV.2 Agreement - investigator compensation - amendment
• T.IV.3 Agreement - subject compensation - amendment
• T.IV.4 Agreement - contract research organization - amendment
• T.IV.5 Agreement - statistical support - amendment