Processing of incoming regular emails depends on whether the incoming regular email is the original/first incoming regular email in the correspondence or one of the incoming regular email replies in the correspondence.

The original/first incoming regular email receives full manual enrichment processing by the corporate end user.

Regular email replies are in most cases automatically processed by the Relational Email Server. The only exception is when the Theme is Corporate Entities and the regular email reply contains attachment(s). In this case, prior to processing, manual classification of the attachment(s) must be done by the corporate end user.

Document classification has to be done in accordance with the General Document Classification presented in the corresponding section of this site. Depending on the selected Corporate Entity topic/subtopic combination, a List of Values of the corresponding document classes is displayed to chose from. 

A list of corresponding documents for each corporate entity subtopic is presented here.

For instance, if the attached document is a person's CV, the list of contacts for the Organization selected as the topic is displayed to choose from.

All attached documents are uploaded with the status "initially processed" and, depending on the selected topic/subtopic combination, can be seen  on one of the entity change application forms for further processing. 

Further processing can be done by the designated entity person his Assistant or his Agent for the selected Corporate Entity.

All "initially processed" attachments of registered email correspondence can be seen on the sub-application form "Correspondence" of the corresponding entity change application form.

The main objective of further documentation processing is to determine whether the incoming document(s) is "basis for change" of the Corporate Entity  and consequently, whether to initiate a Corporate Project to change the Corporate Entity.

Further processing can only be done by the designated corporate entity person his Agent or his Assistant for the Corporate Entity chosen as the topic in enriched email correspondence. When enough "basis for change" documents are gathered to determine the type of change proper "Variation" is selected and a Corporate Project is initiated.

The details of this process are described in the Corporate Entity section of this site for each type of Corporate Entity.

For instance, when corresponding with a Monitoring Organization regarding a Clinical Trial Realization Project involving several Investigational Sites, the Investigational Site may be selected to point to the Investigational Site as the subject of the correspondence.

For instance, for the significant event "Favorable opinion by IRB/IEC", the feature "completeness" is used to change project activity when all Ethical Committees provided positive opinions. Details for this example are provided in the "Clinical Trial Authorization Project" document.

The relation of Corporate Projects, their activities and related significant events is elaborated in detail in the section of this site related to Corporate Projects.

Depending on the type of the selected Corporate Project and its current activity, the LoV of the possible attached documents  is displayed to chose from. In case the attached document is based on a company template, automatic classification is provided.

The relation of Corporate Projects, their activities, events and related documents is elaborated in detail in the section of this site related to Corporate Projects.

Depending on the content of the email message and attached documents actions may be necessary from the involved pre-clinical, clinical, quality/cmc, regulatory and marketing entity designated persons.

Actions are initiated by issuing requests for Additional Info or eCTD editorial processing of relevant files.

Details of this process are described in the Corporate Projects  section of this site.